Background: The Mediterranean Diet (MD) can be described as the healthy dietary pattern characterized by high consumption of vegetables and low consumption of full fat dairy products and red meat. Unhealthy lifestyle and obesity are the most probable causes of fatty liver (FL). Adherence to MD is a significant predictor of changes in the fat content of the liver in overweight patients with FL. Fatty Liver Index (FLI) is a clinical and metabolic correlate of FL used as surrogate parameters for liver fat content in general population. Visceral adiposity Index (VAI) is a gender-specific index of adiposity assessment highly correlated with cardiometabolic risk. Aim: To evaluate the correlations between MD adherence with FLI and VAI. Materials and methods: Fifty severely obese individuals (19 M and 31 F, mean age 36.9±8.3 and 36.1±10.1 yrs, respectively) were included in this study. A validated 14-item questionnaire (PREDIMED) was used to assess MD adherence score (poor adherence 0-5; average adherence 6-9; better than average adherence 10). Homeostasis model assessment (HoMA-IR) index was calculated according to the formula, (serum glucose [mg/dL] × insulin [μIU/mL])/405. FLI and VAI were calculated according to Bedogni G. et al.1and Amato MC et al.2, respectively. Results: According to PREDIMED, 46% of the population presented with poor adherence, 46% average adherence and 8% better than average adherence to the MD. High FLI score was evidenced in all the subjects. High VAI score was evidenced in 92% of the subjects. MD adherence was significantly correlated with BMI (r=-0.541, p<0.001), WC (r=-0.660, p<0.001), HoMA-IR (r=-0.531, p=0.014), FLI (r=-0.617, p<0.001), VAI (r=-0.323, p=0.022). At multiple regression analysis, MD adherence was the major predictor of FLI (β=-0.621, t=-5.3, p<0.001). Conclusions: The correlation between MD adherence and FLI, as a surrogate index of FL, a source of inflammatory factors contributing to cardiovascular and neoplastic diseases risk, confirms that in obese subjects MD could serve as an anti-inflammatory dietary pattern. 1Bedogni G. et al. BMC Gastroenterol. 2006 Nov 2;6:33 2Amato MC et al. Lipids Health Dis. 2011 Oct 19;10:183
Adherence to Mediterranean Diet and Fatty Liver Index (FLI)
Barrea L;
2012-01-01
Abstract
Background: The Mediterranean Diet (MD) can be described as the healthy dietary pattern characterized by high consumption of vegetables and low consumption of full fat dairy products and red meat. Unhealthy lifestyle and obesity are the most probable causes of fatty liver (FL). Adherence to MD is a significant predictor of changes in the fat content of the liver in overweight patients with FL. Fatty Liver Index (FLI) is a clinical and metabolic correlate of FL used as surrogate parameters for liver fat content in general population. Visceral adiposity Index (VAI) is a gender-specific index of adiposity assessment highly correlated with cardiometabolic risk. Aim: To evaluate the correlations between MD adherence with FLI and VAI. Materials and methods: Fifty severely obese individuals (19 M and 31 F, mean age 36.9±8.3 and 36.1±10.1 yrs, respectively) were included in this study. A validated 14-item questionnaire (PREDIMED) was used to assess MD adherence score (poor adherence 0-5; average adherence 6-9; better than average adherence 10). Homeostasis model assessment (HoMA-IR) index was calculated according to the formula, (serum glucose [mg/dL] × insulin [μIU/mL])/405. FLI and VAI were calculated according to Bedogni G. et al.1and Amato MC et al.2, respectively. Results: According to PREDIMED, 46% of the population presented with poor adherence, 46% average adherence and 8% better than average adherence to the MD. High FLI score was evidenced in all the subjects. High VAI score was evidenced in 92% of the subjects. MD adherence was significantly correlated with BMI (r=-0.541, p<0.001), WC (r=-0.660, p<0.001), HoMA-IR (r=-0.531, p=0.014), FLI (r=-0.617, p<0.001), VAI (r=-0.323, p=0.022). At multiple regression analysis, MD adherence was the major predictor of FLI (β=-0.621, t=-5.3, p<0.001). Conclusions: The correlation between MD adherence and FLI, as a surrogate index of FL, a source of inflammatory factors contributing to cardiovascular and neoplastic diseases risk, confirms that in obese subjects MD could serve as an anti-inflammatory dietary pattern. 1Bedogni G. et al. BMC Gastroenterol. 2006 Nov 2;6:33 2Amato MC et al. Lipids Health Dis. 2011 Oct 19;10:183I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
