Background: Obesity is related to reproductive disorders in both males and females. Little information is available on the relationships between obesity, alterations in semen parameters, and cardiometabolic risk. Aim: To investigate the relationships between obesity, body composition, alterations in semen parameters, and cardiometabolic risk in young obese men. Materials and Methods: Thirty men with severe obesity (BMI 43.2±5.7 kg/m2, age 36.2±10.7 yrs) were recruited. Antropometric parameters, FSH, LH, WHVWRVWHURQH 7 ȕ HVWUDGLRO OHYHOV ZHUH HYDOXDWHG 7KH +R0$ +RPHRVWDVLV0RGHO Assessment) index and Visceral Adiposity Index (VAI), were calculated. Metabolic Syndrome (MS) was diagnosed according to ATP III criteria. Semen samples were taken from each patient by masturbation after 2-5 days of abstinence and assessed according to the WHO criteria. Body composition was performed with bioimpedance analysis and biavector analysis. Results: MS was diagnosed in 54.5%. Normospermia was present in 43.3% of the study population, and oligoazoospermia in 56.7%. T levels were positively correlated with total sperm count (SC), sperm motility (SM), and sperm motility rapid progression (SMRP) (r=0.658, p<0.001, r=0.464, p=0.001; r=0.492, p=0.006, respectively). BMI was negatively correlated with total SC and T levels (r=-0.547, p=0.002; r=-0.558, p=0.001, respectively). A negative correlation was observed between % fat mass and total SC, SM, and SMRP (r=-0.408, p=0.025; r=-0.425, p=0.019; r=-0.471, p=0.009). Fat mass was negatively correlated with T levels (r=-0.460, p=0.011), while free fat mass was positively correlated total SC, SM, SMRP and T levels (r=0.575; p=0.001; r=0.388; p=0.034; r=0.551; p=0.002; r=0.677, p<0.001, respectively). VAI was positively correlated with HoMA index (r=0.506, p=0.004) and negatively with SM and SMRP (r=-0.435, p=0.016 and r=-0.388, p=0.034, respectively). At multiple regression analysis, T was the PDMRU GHWHUPLQDQWV RI WRWDO 6& ȕ S ZKLOH 9$, ZHOOSUHGLFWHG60DQG 6053 ȕ S DQG ȕ S UHVSHFWLYHO\ &RQFOXVLRQV 9LVFHUDO adipose tissue dysfunction, expressed by VAI, might affect the semen plasma quality and, consequently, male infertility in young males with severe obesity, likely through the increased release of inflammatory adipokines. The evaluation of VAI, apart from the cardiometabolic risk, could help to better identify the young obese men at risk of impaired semen plasma quality.
USEFULNESS OF VISCERAL ADIPOSITY INDEX (VAI) IN THE EVALUATION OF ALTERATIONS IN SEMEN PARAMETERS AND CARDIOMETABOLIC RISK IN YOUNG OBESE MALES
Barrea L;
2013-01-01
Abstract
Background: Obesity is related to reproductive disorders in both males and females. Little information is available on the relationships between obesity, alterations in semen parameters, and cardiometabolic risk. Aim: To investigate the relationships between obesity, body composition, alterations in semen parameters, and cardiometabolic risk in young obese men. Materials and Methods: Thirty men with severe obesity (BMI 43.2±5.7 kg/m2, age 36.2±10.7 yrs) were recruited. Antropometric parameters, FSH, LH, WHVWRVWHURQH 7 ȕ HVWUDGLRO OHYHOV ZHUH HYDOXDWHG 7KH +R0$ +RPHRVWDVLV0RGHO Assessment) index and Visceral Adiposity Index (VAI), were calculated. Metabolic Syndrome (MS) was diagnosed according to ATP III criteria. Semen samples were taken from each patient by masturbation after 2-5 days of abstinence and assessed according to the WHO criteria. Body composition was performed with bioimpedance analysis and biavector analysis. Results: MS was diagnosed in 54.5%. Normospermia was present in 43.3% of the study population, and oligoazoospermia in 56.7%. T levels were positively correlated with total sperm count (SC), sperm motility (SM), and sperm motility rapid progression (SMRP) (r=0.658, p<0.001, r=0.464, p=0.001; r=0.492, p=0.006, respectively). BMI was negatively correlated with total SC and T levels (r=-0.547, p=0.002; r=-0.558, p=0.001, respectively). A negative correlation was observed between % fat mass and total SC, SM, and SMRP (r=-0.408, p=0.025; r=-0.425, p=0.019; r=-0.471, p=0.009). Fat mass was negatively correlated with T levels (r=-0.460, p=0.011), while free fat mass was positively correlated total SC, SM, SMRP and T levels (r=0.575; p=0.001; r=0.388; p=0.034; r=0.551; p=0.002; r=0.677, p<0.001, respectively). VAI was positively correlated with HoMA index (r=0.506, p=0.004) and negatively with SM and SMRP (r=-0.435, p=0.016 and r=-0.388, p=0.034, respectively). At multiple regression analysis, T was the PDMRU GHWHUPLQDQWV RI WRWDO 6& ȕ S ZKLOH 9$, ZHOOSUHGLFWHG60DQG 6053 ȕ S DQG ȕ S UHVSHFWLYHO\ &RQFOXVLRQV 9LVFHUDO adipose tissue dysfunction, expressed by VAI, might affect the semen plasma quality and, consequently, male infertility in young males with severe obesity, likely through the increased release of inflammatory adipokines. The evaluation of VAI, apart from the cardiometabolic risk, could help to better identify the young obese men at risk of impaired semen plasma quality.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
