Background The Mediterranean diet (MD) can be described as a healthy dietary pattern with anti-inflammatory properties, characterized by high consumption of vegetables and low consumption of full fat dairy products and red meat. Unhealthy lifestyle and obesity are the most probable causes of fatty liver (FL). Adherence to MD is a significant predictor of changes in the fat content of the liver in overweight patients with FL. Fatty Liver Index (FLI) is a clinical and metabolic correlate of FL used as surrogate parameters for liver fat content in the general population. Visceral Adiposity Index (VAI) is a gender-specific index of visceral adiposity highly correlated with cardiometabolic risk. Aim To evaluate the correlations of MD adherence with FLI and VAI. Materials and methods Fifty severely obese individuals (19 M and 31 F, mean age 36.9 ± 8.3 and 36.1 ± 10.1 years, respectively) were included in this study. A validated 14-item questionnaire (PREDIMED) was used to assess MD adherence score (poor adherence 0–5; average adherence 6–9; better than average adherence C10). Homeostasis model assessment of insulin resistance (HoMA-IR) index was calculated according to the formula: serum glucose [mg/ dL] 9 insulin [IU/mL])/405. FLI and VAI were calculated according to Bedogni G et al.1 and Amato MC et al.2 , respectively. Results According to PREDIMED, 46 % of the population presented with poor adherence, 46 % average adherence and 8 % better than average adherence to the MD. High FLI score was evidenced in all the subjects. High VAI score was evidenced in 92 % of the subjects. MD adherence was significantly correlated with BMI (r = -0.541, p\0.001), waist circumference (r = -0.660, p\0.001), HoMAIR (r = -0.531, p = 0.014), FLI (r = -0.617, p\0.001), VAI (r = -0.323, p = 0.022). At multiple regression analysis, MD adherence was the major predictor of FLI (b = -0.621, t = -5.3, p\0.001). Conclusions Considering the role of FL as source of inflammatory factors contributing to the risk of cardiovascular and neoplastic diseases, the correlation between MD adherence and FLI, as a surrogate index of FL, confirms that in obese subjects MD could serve as an anti-inflammatory dietary pattern. 1 Bedogni G et al. BMC Gastroenterol. 2006;6:33. 2 Amato MC et al. Lipids Health Dis. 2011;10:183.
P24 ADHERENCE TO MEDITERRANEAN DIET AND FATTY LIVER INDEX (FLI)
BARREA L;
2014-01-01
Abstract
Background The Mediterranean diet (MD) can be described as a healthy dietary pattern with anti-inflammatory properties, characterized by high consumption of vegetables and low consumption of full fat dairy products and red meat. Unhealthy lifestyle and obesity are the most probable causes of fatty liver (FL). Adherence to MD is a significant predictor of changes in the fat content of the liver in overweight patients with FL. Fatty Liver Index (FLI) is a clinical and metabolic correlate of FL used as surrogate parameters for liver fat content in the general population. Visceral Adiposity Index (VAI) is a gender-specific index of visceral adiposity highly correlated with cardiometabolic risk. Aim To evaluate the correlations of MD adherence with FLI and VAI. Materials and methods Fifty severely obese individuals (19 M and 31 F, mean age 36.9 ± 8.3 and 36.1 ± 10.1 years, respectively) were included in this study. A validated 14-item questionnaire (PREDIMED) was used to assess MD adherence score (poor adherence 0–5; average adherence 6–9; better than average adherence C10). Homeostasis model assessment of insulin resistance (HoMA-IR) index was calculated according to the formula: serum glucose [mg/ dL] 9 insulin [IU/mL])/405. FLI and VAI were calculated according to Bedogni G et al.1 and Amato MC et al.2 , respectively. Results According to PREDIMED, 46 % of the population presented with poor adherence, 46 % average adherence and 8 % better than average adherence to the MD. High FLI score was evidenced in all the subjects. High VAI score was evidenced in 92 % of the subjects. MD adherence was significantly correlated with BMI (r = -0.541, p\0.001), waist circumference (r = -0.660, p\0.001), HoMAIR (r = -0.531, p = 0.014), FLI (r = -0.617, p\0.001), VAI (r = -0.323, p = 0.022). At multiple regression analysis, MD adherence was the major predictor of FLI (b = -0.621, t = -5.3, p\0.001). Conclusions Considering the role of FL as source of inflammatory factors contributing to the risk of cardiovascular and neoplastic diseases, the correlation between MD adherence and FLI, as a surrogate index of FL, confirms that in obese subjects MD could serve as an anti-inflammatory dietary pattern. 1 Bedogni G et al. BMC Gastroenterol. 2006;6:33. 2 Amato MC et al. Lipids Health Dis. 2011;10:183.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
