Clinical recurrence within 5 yr after surgery was the most informative endpoint in predicting long-term overall survival in surgically treated high-risk patients. In men with biochemical recurrence, clinical recurrence within the next 12 mo was the most informative intermediate clinical endpoint. These results should be taken into account for optimal follow-up schedules and for the design of future trials developed in the high-risk setting.

Defining the Most Informative Intermediate Clinical Endpoints for Predicting Overall Survival in Patients Treated with Radical Prostatectomy for High-risk Prostate Cancer

Mirone V.;
2019-01-01

Abstract

Clinical recurrence within 5 yr after surgery was the most informative endpoint in predicting long-term overall survival in surgically treated high-risk patients. In men with biochemical recurrence, clinical recurrence within the next 12 mo was the most informative intermediate clinical endpoint. These results should be taken into account for optimal follow-up schedules and for the design of future trials developed in the high-risk setting.
2019
Biochemical recurrence
Clinical recurrence
Delta recurrence
Metastasis
Overall survival
Aged
Humans
Kaplan-Meier Estimate
Lymph Node Excision
Male
Middle Aged
Neoplasm Recurrence
Local
Pelvis
Proportional Hazards Models
Prostatic Neoplasms
Prostatectomy
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12607/35824
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