We analyzed the effects of seletracetam (ucb 44212; SEL), a new antiepileptic drug candidate, in an in vitro model of epileptic activity. The activity of SEL was compared to the effects of levetiracetam (LEV; Keppra), in the same assays.

Seletracetam (ucb 44212) inhibits high-voltage-activated Ca(2+) currents and intracellular Ca(2+) increase in rat cortical neurons in vitro

MARTELLA G;
2008-01-01

Abstract

We analyzed the effects of seletracetam (ucb 44212; SEL), a new antiepileptic drug candidate, in an in vitro model of epileptic activity. The activity of SEL was compared to the effects of levetiracetam (LEV; Keppra), in the same assays.
2008
Animals
Calcium
Dose-Response Relationship
Drug
Pyrrolidinones
Bicuculline
Calcium Channel Blockers
Neural Inhibition
Biophysics
Rats
Calcium Channels
GABA Antagonists
Patch-Clamp Techniques
Neurons
Rats
Wistar
Potassium Channel Blockers
Piracetam
Membrane Potentials
4-Aminopyridine
Magnesium
Neocortex
Anticonvulsants
Male
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12607/4439
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