Background: Cancer survivors frequently experience persistent physical and psychological sequelae, including impaired physical function, fatigue, anxiety/depressive symptoms, and reduced health-related quality of life (HRQoL). Exercise is an effective non-pharmacological intervention; however, comparative evidence between multicomponent training (MCT) and aerobic training (AT) using a multidomain framework remains limited. Methods: In this randomized controlled parallel-group trial, 47 cancer survivors (mean age 63.0 ± 8.9 years) were allocated to a 24-week supervised MCT programme (n = 16), an AT programme (n = 16), or a non-exercise control group (CG; n = 15). Outcomes were assessed at baseline and post-intervention including body composition (BIA), physical performance, fatigue (FSS), anxiety (STAI-Y1/Y2), depressive symptoms (BDI), and HRQoL (EORTC QLQ-C30). Results: Fat mass decreased in both MCT (p = 0.005) and AT (p = 0.034), whereas arm cir- cumference increased only in MCT (p < 0.001). Significant Group × Time interactions were observed for major physical performance outcomes; improvements were broader in MCT, while AT showed its largest change in aerobic endurance. Between-group contrasts indi- cated greater gains with MCT than AT for chair-stand (p = 0.046), sit-and-reach (p = 0.048), and handgrip strength (p = 0.049). Significant interaction effects were also observed for fatigue and psychological outcomes (FSS: p = 0.003; STAI-Y1 and STAI-Y2: p < 0.001; BDI: p < 0.001) and for HRQoL global health (p = 0.003), with larger improvements in MCT than AT for fatigue, state anxiety, and depressive symptoms (all p < 0.05), but not for trait anxiety (p > 0.05). Conclusions: A 24-week supervised MCT programme produced broader benefits than AT alone across physical function and selected psychological outcomes in cancer survivors. These findings support the incorporation of multicomponent exercise
Effects of Multicomponent Versus Aerobic Training on Body Composition, Physical Fitness, Psychological Health, and Quality of Life in Cancer Survivors: A 24-Week Randomized Controlled Trial
Stefania Cataldi
2026-01-01
Abstract
Background: Cancer survivors frequently experience persistent physical and psychological sequelae, including impaired physical function, fatigue, anxiety/depressive symptoms, and reduced health-related quality of life (HRQoL). Exercise is an effective non-pharmacological intervention; however, comparative evidence between multicomponent training (MCT) and aerobic training (AT) using a multidomain framework remains limited. Methods: In this randomized controlled parallel-group trial, 47 cancer survivors (mean age 63.0 ± 8.9 years) were allocated to a 24-week supervised MCT programme (n = 16), an AT programme (n = 16), or a non-exercise control group (CG; n = 15). Outcomes were assessed at baseline and post-intervention including body composition (BIA), physical performance, fatigue (FSS), anxiety (STAI-Y1/Y2), depressive symptoms (BDI), and HRQoL (EORTC QLQ-C30). Results: Fat mass decreased in both MCT (p = 0.005) and AT (p = 0.034), whereas arm cir- cumference increased only in MCT (p < 0.001). Significant Group × Time interactions were observed for major physical performance outcomes; improvements were broader in MCT, while AT showed its largest change in aerobic endurance. Between-group contrasts indi- cated greater gains with MCT than AT for chair-stand (p = 0.046), sit-and-reach (p = 0.048), and handgrip strength (p = 0.049). Significant interaction effects were also observed for fatigue and psychological outcomes (FSS: p = 0.003; STAI-Y1 and STAI-Y2: p < 0.001; BDI: p < 0.001) and for HRQoL global health (p = 0.003), with larger improvements in MCT than AT for fatigue, state anxiety, and depressive symptoms (all p < 0.05), but not for trait anxiety (p > 0.05). Conclusions: A 24-week supervised MCT programme produced broader benefits than AT alone across physical function and selected psychological outcomes in cancer survivors. These findings support the incorporation of multicomponent exerciseI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
